Protein-coding gene in the species Homo sapiens
ANKRD23 |
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Identifiers |
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Aliases | ANKRD23, DARP, MARP3, ankyrin repeat domain 23 |
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External IDs | OMIM: 610736; MGI: 1925571; HomoloGene: 14025; GeneCards: ANKRD23; OMA:ANKRD23 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 2 (human)[1] |
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| Band | 2q11.2 | Start | 96,824,526 bp[1] |
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End | 96,857,934 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 1 (mouse)[2] |
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| Band | 1|1 B | Start | 36,569,269 bp[2] |
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End | 36,575,964 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - muscle of thigh
- gastrocnemius muscle
- sural nerve
- tibialis anterior muscle
- skeletal muscle tissue
- quadriceps femoris muscle
- vastus lateralis muscle
- right uterine tube
- apex of heart
- biceps brachii
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| Top expressed in | - quadriceps femoris muscle
- muscle tissue
- muscle of thigh
- skeletal muscle tissue
- esophagus
- zone of skin
- lip
- heart
- adrenal gland
- neural layer of retina
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | | Cellular component | - myofibril
- nucleus
- intercalated disc
- nucleoplasm
- actin cytoskeleton
- cytosol
| Biological process | - response to mechanical stimulus
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 2: 96.82 – 96.86 Mb | Chr 1: 36.57 – 36.58 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Ankyrin repeat domain-containing protein 23 is a protein that in humans is encoded by the ANKRD23 gene.[5][6]
This gene is a member of the muscle ankyrin repeat protein (MARP) family and encodes a protein with four tandem ankyrin-like repeats. The protein is localized to the nucleus, functioning as a transcriptional regulator. Expression of this protein is induced during recovery following starvation.[6]
Interactions
ANKRD23 has been shown to interact with Titin[7] and MYPN.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000163126 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067653 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Ikeda K, Emoto N, Matsuo M, Yokoyama M (Feb 2003). "Molecular identification and characterization of a novel nuclear protein whose expression is up-regulated in insulin-resistant animals". J Biol Chem. 278 (6): 3514–20. doi:10.1074/jbc.M204563200. PMID 12456686.
- ^ a b "Entrez Gene: ANKRD23 ankyrin repeat domain 23".
- ^ a b Miller, Melanie K; Bang Marie-Louise; Witt Christian C; Labeit Dietmar; Trombitas Charles; Watanabe Kaori; Granzier Henk; McElhinny Abigail S; Gregorio Carol C; Labeit Siegfried (Nov 2003). "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules". J. Mol. Biol. 333 (5): 951–64. doi:10.1016/j.jmb.2003.09.012. ISSN 0022-2836. PMID 14583192.
External links
Further reading
- Hillier LW; Graves TA; Fulton RS; et al. (2005), "Generation and annotation of the DNA sequences of human chromosomes 2 and 4", Nature, 434 (7034): 724–31, Bibcode:2005Natur.434..724H, doi:10.1038/nature03466, PMID 15815621
- Gerhard DS; Wagner L; Feingold EA; et al. (2004), "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)", Genome Res., 14 (10B): 2121–7, doi:10.1101/gr.2596504, PMC 528928, PMID 15489334
- Nagueh SF; Shah G; Wu Y; et al. (2005), "Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy", Circulation, 110 (2): 155–62, doi:10.1161/01.CIR.0000135591.37759.AF, PMID 15238456
- Ota T; Suzuki Y; Nishikawa T; et al. (2004), "Complete sequencing and characterization of 21,243 full-length human cDNAs", Nat. Genet., 36 (1): 40–5, doi:10.1038/ng1285, PMID 14702039
- Miller MK; Bang ML; Witt CC; et al. (2003), "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules", J. Mol. Biol., 333 (5): 951–64, doi:10.1016/j.jmb.2003.09.012, PMID 14583192
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003), "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences", Proc. Natl. Acad. Sci. U.S.A., 99 (26): 16899–903, Bibcode:2002PNAS...9916899M, doi:10.1073/pnas.242603899, PMC 139241, PMID 12477932
- Dias Neto E; Correa RG; Verjovski-Almeida S; et al. (2000), "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags", Proc. Natl. Acad. Sci. U.S.A., 97 (7): 3491–6, Bibcode:2000PNAS...97.3491D, doi:10.1073/pnas.97.7.3491, PMC 16267, PMID 10737800