PRKCD |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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2YUU, 1YRK |
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Identifiers |
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Aliases | PRKCD, ALPS3, CVID9, MAY1, PKCD, nPKC-delta, protein kinase C delta |
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External IDs | OMIM: 176977; MGI: 97598; HomoloGene: 55963; GeneCards: PRKCD; OMA:PRKCD - orthologs |
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EC number | 2.7.10.2 |
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Gene location (Human) |
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| Chr. | Chromosome 3 (human)[1] |
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| Band | 3p21.1 | Start | 53,156,009 bp[1] |
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End | 53,192,717 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 14 (mouse)[2] |
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| Band | 14 B|14 18.82 cM | Start | 30,317,311 bp[2] |
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End | 30,348,167 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - monocyte
- granulocyte
- right adrenal cortex
- right uterine tube
- mucosa of transverse colon
- left adrenal gland
- left adrenal cortex
- right lobe of thyroid gland
- left lobe of thyroid gland
- rectum
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| Top expressed in | - lateral geniculate nucleus
- granulocyte
- medial dorsal nucleus
- medial geniculate nucleus
- lateral septal nucleus
- pyloric antrum
- seminiferous tubule
- epithelium of stomach
- large intestine
- colon
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| More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - kinase activity
- ATP binding
- protein kinase activity
- non-membrane spanning protein tyrosine kinase activity
- metal ion binding
- kinase binding
- enzyme binding
- insulin receptor substrate binding
- transferase activity
- protein binding
- calcium-independent protein kinase C activity
- protein kinase binding
- nucleotide binding
- enzyme activator activity
- protein serine/threonine kinase activity
- protein kinase C activity
| Cellular component | - cytoplasm
- cytosol
- membrane
- cell-cell junction
- perinuclear region of cytoplasm
- nucleus
- nuclear matrix
- endoplasmic reticulum
- extracellular exosome
- plasma membrane
- nucleoplasm
- extracellular region
- azurophil granule lumen
| Biological process | - intrinsic apoptotic signaling pathway in response to oxidative stress
- termination of signal transduction
- interferon-gamma-mediated signaling pathway
- negative regulation of protein binding
- positive regulation of endodeoxyribonuclease activity
- platelet activation
- protein phosphorylation
- cellular senescence
- negative regulation of insulin receptor signaling pathway
- positive regulation of sphingomyelin catabolic process
- cell chemotaxis
- cell cycle
- negative regulation of inflammatory response
- positive regulation of protein dephosphorylation
- Fc-gamma receptor signaling pathway involved in phagocytosis
- positive regulation of apoptotic signaling pathway
- stimulatory C-type lectin receptor signaling pathway
- cellular response to hydroperoxide
- negative regulation of peptidyl-tyrosine phosphorylation
- defense response to bacterium
- negative regulation of MAP kinase activity
- positive regulation of response to DNA damage stimulus
- positive regulation of protein import into nucleus
- interleukin-10 production
- regulation of actin cytoskeleton organization
- negative regulation of actin filament polymerization
- regulation of mRNA stability
- phosphorylation
- protein stabilization
- regulation of signaling receptor activity
- negative regulation of filopodium assembly
- cellular response to angiotensin
- interleukin-12 production
- peptidyl-threonine phosphorylation
- positive regulation of ceramide biosynthetic process
- neutrophil activation
- intracellular signal transduction
- negative regulation of glial cell apoptotic process
- negative regulation of platelet aggregation
- positive regulation of phospholipid scramblase activity
- B cell proliferation
- immunoglobulin mediated immune response
- positive regulation of glucosylceramide catabolic process
- peptidyl-tyrosine phosphorylation
- positive regulation of superoxide anion generation
- activation of protein kinase activity
- signal transduction
- cellular response to hydrogen peroxide
- peptidyl-serine phosphorylation
- apoptotic process
- neutrophil degranulation
- execution phase of apoptosis
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_006254 NM_212539 NM_001316327 NM_001354676 NM_001354678
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NM_001354679 NM_001354680 |
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RefSeq (protein) | NP_001303256 NP_006245 NP_997704 NP_001341605 NP_001341607
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NP_001341608 NP_001341609 |
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Location (UCSC) | Chr 3: 53.16 – 53.19 Mb | Chr 14: 30.32 – 30.35 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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