PWP2

Protein-coding gene in the species Homo sapiens
PWP2
Identifiers
AliasesPWP2, EHOC-17, PWP2H, UTP1, PWP2 periodic tryptophan protein homolog (yeast), small subunit processome component, PWP2 small subunit processome component
External IDsOMIM: 601475; MGI: 1341200; HomoloGene: 136786; GeneCards: PWP2; OMA:PWP2 - orthologs
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for PWP2
Genomic location for PWP2
Band21q22.3Start44,107,373 bp[1]
End44,131,181 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for PWP2
Genomic location for PWP2
Band10 C1|10 39.72 cMStart78,006,743 bp[2]
End78,020,983 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • corpus callosum

  • mucosa of transverse colon

  • gastric mucosa

  • gonad

  • skeletal muscle tissue

  • sural nerve

  • prefrontal cortex

  • right adrenal gland

  • blood
Top expressed in
  • primitive streak

  • epiblast

  • primary oocyte

  • otic vesicle

  • secondary oocyte

  • otic placode

  • cumulus cell

  • zygote

  • ventricular zone

  • yolk sac
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • snoRNA binding
  • RNA binding
Cellular component
  • Pwp2p-containing subcomplex of 90S preribosome
  • nucleus
  • nucleolus
  • small-subunit processome
  • nucleoplasm
Biological process
  • ribosomal small subunit assembly
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • rRNA processing
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5822

110816

Ensembl

ENSG00000241945

ENSMUSG00000032834

UniProt

Q15269

Q8BU03

RefSeq (mRNA)

NM_005049

NM_029546

RefSeq (protein)

NP_005040

NP_083822

Location (UCSC)Chr 21: 44.11 – 44.13 MbChr 10: 78.01 – 78.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Periodic tryptophan protein 2 homolog is a protein that in humans is encoded by the PWP2 gene.[5][6]

Function

This protein is involved in the assembly of small subunit of ribosome.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000241945 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032834 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yamakawa K, Gao DQ, Korenberg JR (Dec 1996). "A periodic tryptophan protein 2 gene homologue (PWP2H) in the candidate region of progressive myoclonus epilepsy on 21q22.3". Cytogenet Cell Genet. 74 (1–2): 140–5. doi:10.1159/000134402. PMID 8893822.
  6. ^ a b "PWP2 PWP2 small subunit processome component [ Homo sapiens (human) ]".

Further reading

  • Lalioti MD, Chen H, Rossier C, et al. (1996). "Cloning the cDNA of human PWP2, which encodes a protein with WD repeats and maps to 21q22.3". Genomics. 35 (2): 321–7. doi:10.1006/geno.1996.0363. PMID 8661145.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Lafrenière RG, Rochefort DL, Chrétien N, et al. (1997). "Isolation and genomic structure of a human homolog of the yeast periodic tryptophan protein 2 (PWP2) gene mapping to 21q22.3". Genome Res. 6 (12): 1216–26. doi:10.1101/gr.6.12.1216. PMID 8973917.
  • Nagamine K, Kudoh J, Kawasaki K, et al. (1997). "Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3". Biochem. Biophys. Res. Commun. 235 (1): 185–90. doi:10.1006/bbrc.1997.6758. PMID 9196060.
  • Nagamine K, Kudoh J, Minoshima S, et al. (1997). "Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21". Genomics. 42 (3): 528–31. doi:10.1006/geno.1997.4761. PMID 9205129.
  • Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
  • Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


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