SEC14L1

Protein-coding gene in the species Homo sapiens
SEC14L1
Identifiers
AliasesSEC14L1, PRELID4A, SEC14L, SEC14 like lipid binding 1
External IDsOMIM: 601504; MGI: 1921386; HomoloGene: 37719; GeneCards: SEC14L1; OMA:SEC14L1 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for SEC14L1
Genomic location for SEC14L1
Band17q25.2-q25.3Start77,088,749 bp[1]
End77,217,101 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for SEC14L1
Genomic location for SEC14L1
Band11|11 E2Start117,005,994 bp[2]
End117,050,094 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • dorsal motor nucleus of vagus nerve

  • internal globus pallidus

  • blood

  • inferior olivary nucleus

  • lower lobe of lung

  • right lung

  • pericardium

  • olfactory bulb

  • sperm

  • Skeletal muscle tissue of rectus abdominis
Top expressed in
  • submandibular gland

  • superior frontal gyrus

  • neural layer of retina

  • primary visual cortex

  • perirhinal cortex

  • lens

  • granulocyte

  • dorsal striatum

  • molar

  • CA3 field
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • RIG-I binding
  • protein binding
  • molecular function regulator
Cellular component
  • cytoplasm
  • Golgi apparatus
  • nucleoplasm
  • cytosol
Biological process
  • negative regulation of signal transduction
  • innate immune response
  • negative regulation of RIG-I signaling pathway
  • choline transport
  • immune system process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6397

74136

Ensembl

ENSG00000129657

ENSMUSG00000020823

UniProt

Q92503

A8Y5H7

RefSeq (mRNA)
NM_003003
NM_001039573
NM_001143998
NM_001143999
NM_001144001

NM_001204408
NM_001204410

NM_001166506
NM_001166507
NM_028777
NM_001363165

RefSeq (protein)
NP_001034662
NP_001137470
NP_001137471
NP_001137473
NP_001191337

NP_001191339
NP_002994

NP_001159978
NP_001159979
NP_083053
NP_001350094

Location (UCSC)Chr 17: 77.09 – 77.22 MbChr 11: 117.01 – 117.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SEC14-like protein 1 is a protein that in humans is encoded by the SEC14L1 gene.[5][6]

The protein encoded by this gene belongs to the SEC14 cytosolic factor family. It has similarity to yeast SEC14 and to Japanese flying squid RALBP which suggests a possible role of the gene product in an intracellular transport system.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000129657 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020823 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chinen K, Takahashi E, Nakamura Y (Sep 1996). "Isolation and mapping of a human gene (SEC14L), partially homologous to yeast SEC14, that contains a variable number of tandem repeats (VNTR) site in its 3' untranslated region". Cytogenet Cell Genet. 73 (3): 218–23. doi:10.1159/000134342. PMID 8697811.
  6. ^ a b "Entrez Gene: SEC14L1 SEC14-like 1 (S. cerevisiae)".

Further reading

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Kalikin LM, Bugeaud EM, Palmbos PL, et al. (2002). "Genomic characterization of human SEC14L1 splice variants within a 17q25 candidate tumor suppressor gene region and identification of an unrelated embedded expressed sequence tag" (PDF). Mamm. Genome. 12 (12): 925–9. doi:10.1007/s00335-001-2073-3. hdl:2027.42/42124. PMID 11707779. S2CID 1547107.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.


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