TBL3

Protein-coding gene in the species Homo sapiens
TBL3
Identifiers
AliasesTBL3, SAZD, UTP13, transducin beta like 3
External IDsOMIM: 605915; MGI: 2384863; HomoloGene: 4711; GeneCards: TBL3; OMA:TBL3 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for TBL3
Genomic location for TBL3
Band16p13.3Start1,972,053 bp[1]
End1,982,929 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for TBL3
Genomic location for TBL3
Band17|17 A3.3Start24,916,923 bp[2]
End24,926,634 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right testis

  • left testis

  • gastrocnemius muscle

  • apex of heart

  • muscle of thigh

  • skin of leg

  • skin of abdomen

  • ectocervix

  • mucosa of transverse colon

  • right lobe of thyroid gland
Top expressed in
  • spermatocyte

  • epiblast

  • spermatid

  • morula

  • embryo

  • embryo

  • ventricular zone

  • Ileal epithelium

  • maxillary prominence

  • mandibular prominence
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • snoRNA binding
  • RNA binding
Cellular component
  • Pwp2p-containing subcomplex of 90S preribosome
  • small-subunit processome
  • nucleolus
  • nucleus
  • nucleoplasm
Biological process
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • rRNA processing
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10607

213773

Ensembl

ENSG00000183751

ENSMUSG00000040688

UniProt

Q12788

Q8C4J7

RefSeq (mRNA)

NM_006453

NM_145396

RefSeq (protein)

NP_006444

NP_663371

Location (UCSC)Chr 16: 1.97 – 1.98 MbChr 17: 24.92 – 24.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transducin beta-like protein 3 is a protein that in humans is encoded by the TBL3 gene.[5][6]

The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene has multiple polyadenylation sites. It might have multiple alternatively spliced transcript variants but the variants have not been fully described yet.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183751 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040688 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Weinstat-Saslow DL, Germino GG, Somlo S, Reeders ST (Mar 1994). "A transducin-like gene maps to the autosomal dominant polycystic kidney disease gene region". Genomics. 18 (3): 709–11. doi:10.1016/S0888-7543(05)80380-5. PMID 8307582.
  6. ^ a b "Entrez Gene: TBL3 transducin (beta)-like 3".

Further reading

  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.


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