| NR1H3 |
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| Наявні структури |
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| PDB | Пошук ортологів: PDBe RCSB |
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| Список кодів PDB | | 1UHL, 3IPQ, 3IPS, 3IPU, 5AVI, 5AVL, 5HJS | | |
| Ідентифікатори |
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| Символи | NR1H3, LXR-a, LXRA, RLD-1, Liver X receptor alpha, nuclear receptor subfamily 1 group H member 3 |
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| Зовнішні ІД | OMIM: 602423 MGI: 1352462 HomoloGene: 21165 GeneCards: NR1H3 |
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| Пов'язані генетичні захворювання |
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| метаболічні захворювання[1] |
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| Реагує на сполуку |
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| (25R)-cholest-5-ene-3β,26-diol, desmosterol[2] |
| Онтологія гена |
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| Молекулярна функція | • cholesterol binding
• GO:0001948, GO:0016582 protein binding
• zinc ion binding
• GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity
• sterol response element binding
• steroid hormone receptor activity
• DNA binding
• sequence-specific DNA binding
• зв'язування з іоном металу
• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
• GO:0001105 transcription coactivator activity
• GO:0000975 transcription cis-regulatory region binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• transcription factor binding
• nuclear receptor coactivator activity
• signaling receptor activity
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| Клітинна компонента | • receptor complex
• нуклеоплазма
• RNA polymerase II transcription regulator complex
• клітинне ядро
• цитоплазма
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| Біологічний процес | • positive regulation of toll-like receptor 4 signaling pathway
• sterol homeostasis
• negative regulation of pancreatic juice secretion
• negative regulation of inflammatory response
• cellular response to lipopolysaccharide
• negative regulation of lipid transport
• positive regulation of lipoprotein lipase activity
• lipid homeostasis
• triglyceride homeostasis
• negative regulation of macrophage activation
• negative regulation of macrophage derived foam cell differentiation
• positive regulation of cholesterol transport
• negative regulation of cholesterol storage
• GO:0009373 regulation of transcription, DNA-templated
• positive regulation of triglyceride biosynthetic process
• positive regulation of cholesterol efflux
• GO:0051247, GO:0051200 positive regulation of protein metabolic process
• negative regulation of interferon-gamma-mediated signaling pathway
• regulation of circadian rhythm
• transcription, DNA-templated
• GO:1901227 negative regulation of transcription by RNA polymerase II
• response to progesterone
• steroid hormone mediated signaling pathway
• apoptotic cell clearance
• positive regulation of fatty acid biosynthetic process
• transcription initiation from RNA polymerase II promoter
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• negative regulation of secretion of lysosomal enzymes
• negative regulation of pinocytosis
• GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
• intracellular receptor signaling pathway
• cholesterol homeostasis
• lipid metabolism
• multicellular organism development
• диференціація клітин
• negative regulation of cold-induced thermogenesis
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| Джерела:Amigo / QuickGO | |
| Шаблон експресії |
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| Більше даних |
| Ортологи |
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| Види | Людина | Миша |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (мРНК) | | NM_001130101
NM_001130102
NM_001251934
NM_001251935
NM_005693 |
| | NM_001177730
NM_013839
NM_001355279 |
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| RefSeq (білок) | NP_001123573
NP_001123574
NP_001238863
NP_001238864
NP_005684
| NP_001350524
NP_005684.2 |
| | NP_001171201
NP_038867
NP_001342208 |
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| Локус (UCSC) | Хр. 11: 47.25 – 47.27 Mb | Хр. 2: 91.01 – 91.03 Mb |
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| PubMed search | [3] | [4] |
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| Вікідані |
| Див./Ред. для людей | Див./Ред. для мишей |
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